About the Project

Project PREVENT is a test-negative case-control study of health care personnel (HCP) in 20 US academic medical centers. The primary objective of this project is to evaluate SARS-CoV-2 vaccine effectiveness in preventing laboratory-confirmed symptomatic COVID-19 among HCP, specifically focusing on the effect of vaccine boosters and temporal changes in vaccine effectiveness.

Secondary objectives include:

• Identifying differences in vaccine effectiveness by age group and comorbidity categories

• Evaluating vaccine effectiveness within job categories and clinical practice settings,

• Estimating the comparative effectiveness of different SARS-CoV-2 vaccines, vaccine schedules, and time periods between doses,

• Evaluating vaccine effectiveness as related to participant reported history of past infection,

• Measuring effectiveness of SARS-CoV-2 vaccine boosters,

• Elucidating the role of vaccination in preventing prolonged symptoms of COVID-19, and

• Evaluating vaccine effectiveness for illness related to emerging variants.

These questions will be answered by enrolling HCP in participating sites who develop symptoms of COVID-19. After COVID-19 testing, we will define:

• Cases: HCP who test positive for COVID-19, and

• Controls: HCP who test negative for COVID-19.

Study sites are selected to be high-volume academic centers with robust employee testing programs that participate in EMERGEncy ID NET, a CDC-funded emerging infectious disease network created for surveillance and research of emerging infections (PI: David Talan, MD).

Project PREVENT is being administered with the Clinical Coordinating Center at the Geffen School of Medicine at UCLA and the Data Coordinating Center at the University of Iowa.